Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | FABP6 | P51161 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5517671 | 0.84 | TP53 (0.46) | TP53ALDH1A1ATML3MBTL1NPSR1 | |
| SCHEMBL9921218 | 0.80 | TP53 (0.50) | TP53ALDH1A1ATML3MBTL1NPSR1 | |
| SCHEMBL1273104 | 0.78 | TP53 (0.48) | TP53ALDH1A1ATML3MBTL1NPSR1 | |
| SCHEMBL964176 | 0.78 | NCF1 (0.52) | TP53ALDH1A1ATML3MBTL1NPSR1 | |
| SCHEMBL560804 | 0.78 | TP53 (0.48) | TP53ALDH1A1ATML3MBTL1NPSR1 | |
| SCHEMBL24767352 | 0.78 | TP53 (0.44) | TP53ALDH1A1ATML3MBTL1NPSR1 | |
| SCHEMBL7887921 | 0.78 | TP53 (0.44) | TP53ALDH1A1ATML3MBTL1NPSR1 | |
| SCHEMBL24827061 | 0.78 | TP53 (0.48) | TP53ALDH1A1ATML3MBTL1NPSR1 | |
| SCHEMBL1964281 | 0.78 | TP53 (0.44) | TP53ALDH1A1ATML3MBTL1NPSR1 | |
| SCHEMBL772164 | 0.78 | TP53 (0.44) | TP53ALDH1A1ATML3MBTL1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2800745-B1 | PYRROLO CARBOXAMIDES AS MODULATORS OF ORPHAN NUCLEAR RECEPTOR RAR-RELATED ORPHAN RECEPTOR-GAMMA (RORY, NR1F3) ACTIVITY AND FOR THE TREATMENT OF CHRONIC INFLAMMATORY AND AUTOIMMUNE DISEASES | PHENEX PHARMACEUTICALS AG (DE) | 2020-02-12 | — | — | EP | disclosed |