Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 7/20 | 0.33 |
| ▸ | RAB9A | P51151 | 7/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.33 |
| ▸ | RELA | Q04206 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22423677 | 0.67 | PTGS1 (0.34) | NPC1RAB9ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL13258567 | 0.65 | NISCH (0.36) | NPC1RAB9ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL10425527 | 0.62 | ACHE (0.47) | NPC1RAB9ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL28148610 | 0.61 | NOTUM (0.35) | NPC1RAB9ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL30933547 | 0.61 | NPC1 (0.39) | PDE3BPDE3ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL197731 | 0.59 | ACHE (0.73) | ALDH1A1HPGDLMNAENPP3ENPP1 | |
| SCHEMBL3287696 | 0.59 | ACHE (0.73) | ALDH1A1HPGDLMNAENPP3ENPP1 | |
| SCHEMBL18661495 | 0.59 | ACHE (0.73) | ALDH1A1HPGDLMNAENPP3ENPP1 | |
| Water SCHEMBL3763584 | 0.57 | ACHE (0.67) | ALDH1A1HPGDLMNAENPP3ENPP1 | |
| SCHEMBL31498547 | 0.57 | ACHE (0.67) | ALDH1A1HPGDNOTUMLMNAENPP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3608317-A1 | COMPOUNDS & METHODS FOR THE ENHANCED DEGRADATION OF TARGETED PROTEINS & OTHER POLYPEPTIDES BY AN E3 UBIQUITIN LIGASE | Yale University (US) | 2020-02-12 | — | — | EP | disclosed |