Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | ERN1 | O75460 | 3/20 | 0.45 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.44 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | NAAA | Q02083 | 1/20 | 0.43 |
| ▸ | TEK | Q02763 | 1/20 | 0.43 |
| ▸ | ADH1B | P00325 | 1/20 | 0.42 |
| ▸ | ADH1C | P00326 | 1/20 | 0.42 |
| ▸ | ADH1A | P07327 | 1/20 | 0.42 |
| ▸ | ADH7 | P40394 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1844195 | 0.81 | MKNK1 (0.50) | MKNK1MKNK2NPC1LMNAPKM | |
| SCHEMBL13618882 | 0.76 | MKNK1 (0.54) | MKNK1MKNK2NPC1LMNAPKM | |
| SCHEMBL31174412 | 0.75 | CYP2A6 (0.68) | MKNK1MKNK2ERN1HSD17B1HSD17B2 | |
| SCHEMBL3754419 | 0.75 | CYP2A6 (0.68) | MKNK1MKNK2ERN1HSD17B1HSD17B2 | |
| SCHEMBL12516033 | 0.74 | NAAA (0.56) | MKNK1MKNK2NPC1LMNAPKM | |
| SCHEMBL4389483 | 0.74 | MKNK1 (0.53) | MKNK1MKNK2NPC1LMNAPKM | |
| SCHEMBL6213489 | 0.74 | MKNK1 (0.57) | MKNK1MKNK2ERN1HSD17B1HSD17B2 | |
| SCHEMBL3059303 | 0.74 | MKNK1 (0.57) | MKNK1MKNK2NPC1LMNAPKM | |
| SCHEMBL14466730 | 0.73 | MKNK1 (0.51) | MKNK1MKNK2NPC1LMNAPKM | |
| SCHEMBL1842380 | 0.72 | MKNK1 (0.55) | MKNK1MKNK2NPC1LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3608317-A1 | COMPOUNDS & METHODS FOR THE ENHANCED DEGRADATION OF TARGETED PROTEINS & OTHER POLYPEPTIDES BY AN E3 UBIQUITIN LIGASE | Yale University (US) | 2020-02-12 | — | — | EP | disclosed |