Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 11/20 | 0.68 |
| ▸ | CA12 | O43570 | 10/20 | 0.68 |
| ▸ | CA1 | P00915 | 10/20 | 0.68 |
| ▸ | CA9 | Q16790 | 10/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CA7 | P43166 | 1/20 | 0.51 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15126028 | 0.90 | POLB (0.61) | CA2CA12CA1CA9POLB | |
| SCHEMBL21696559 | 0.85 | PKM (0.64) | POLBMEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL21696539 | 0.84 | POLB (0.52) | CA2CA12CA1CA9POLB | |
| SCHEMBL21696931 | 0.83 | POLB (0.56) | CA2CA12CA1CA9POLB | |
| SCHEMBL21696811 | 0.83 | POLB (0.56) | CA2CA12CA1CA9POLB | |
| SCHEMBL15126289 | 0.83 | CA1 (0.62) | CA2CA12CA1CA9CA7 | |
| SCHEMBL21696838 | 0.80 | POLB (0.55) | POLBMEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL21696603 | 0.80 | MEN1 (0.56) | POLBMEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL15126354 | 0.80 | MEN1 (0.56) | POLBMEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL15125854 | 0.79 | POLB (0.56) | POLBMEN1KMT2ACYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3608317-A1 | COMPOUNDS & METHODS FOR THE ENHANCED DEGRADATION OF TARGETED PROTEINS & OTHER POLYPEPTIDES BY AN E3 UBIQUITIN LIGASE | Yale University (US) | 2020-02-12 | — | — | EP | disclosed |