⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2169763 | 1.00 | — | — | |
| SCHEMBL4380206 | 1.00 | — | — | |
| SCHEMBL9510313 | 0.93 | — | — | |
| SCHEMBL13982681 | 0.91 | — | — | |
| SCHEMBL9506608 | 0.91 | — | — | |
| SCHEMBL9506606 | 0.91 | — | — | |
| SCHEMBL20089272 | 0.77 | — | — | |
| SCHEMBL13588926 | 0.77 | — | — | |
| SCHEMBL1841927 | 0.77 | — | — | |
| SCHEMBL17866585 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11970512-B2 | Amphotericin B derivatives with improved therapeutic index | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2024-04-30 | — | — | US | disclosed |
| CN-110407898-B | Amphotericin B derivatives with improved therapeutic index | 伊利诺伊大学评议会 | 2023-12-01 | — | — | CN | disclosed |
| US-11802125-B2 | Functionalized heterocyclic compounds as antiviral agents | ENANTA PHARMACEUTICALS, INC. | 2023-10-31 | — | — | US | disclosed |
| CN-114560887-A | Preparation method of intermediate for preparing orlistat | 安徽美致诚药业有限公司 | 2022-05-31 | — | — | CN | disclosed |
| US-20210292320-A1 | FUNCTIONALIZED HETEROCYCLIC COMPOUNDS AS ANTIVIRAL AGENTS | ENANTA PHARMACEUTICALS, INC. | 2021-09-23 | — | — | US | disclosed |
| WO-2021188414-A1 | FUNCTIONALIZED HETEROCYCLIC COMPOUNDS AS ANTIVIRAL AGENTS | ENANTA PHARMACEUTICALS, INC. (US) | 2021-09-23 | — | — | WO | disclosed |
| US-9701642-B2 | Method for producing optically active 5-hydroxy-3-ketoester | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2017-07-11 | — | — | US | disclosed |
| EP-2855431-B1 | FSH RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (NL) | 2016-07-06 | — | — | EP | disclosed |
| US-20160185734-A1 | METHOD FOR PRODUCING OPTICALLY ACTIVE 5-HYDROXY-3-KETOESTER | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2016-06-30 | — | — | US | disclosed |
| EP-1472227-B1 | PROCESS FOR THE MANUFACTURE OF ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2016-04-27 | — | — | EP | disclosed |
| WO-1997040859-A1 | BRIDGE-SUBSTITUTED TROPANES AND USES | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 1997-11-06 | — | — | WO | disclosed |
| US-5506359-A | TROPANE COMPOUNDS USEFUL FOR IMAGING AND TREATING PARKINSON'S DISEASE AND COCAINE ABUSE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 1996-04-09 | — | — | US | disclosed |
| WO-1994004146-A1 | COCAINE ANALOGUES AND THEIR USE AS COCAINE DRUG THERAPIES AND THERAPEUTIC AND IMAGING AGENTS FOR NEURODEGENERATIVE DISORDERS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 1994-03-03 | — | — | WO | disclosed |
| EP-0271829-B1 | DELTA-HYDROXY-BETA-LYSINE DERIVATIVES AND THEIR PRODUCTION | Takeda Chemical Industries, Ltd. (JP) | 1993-08-25 | — | — | EP | disclosed |
| US-5120848-A | Anticholesterol and antilipemic agents; hydroxy-3-methylglutaryl/3-/ coenzyme A reductase inhibitors | GLAXO GROUP LIMITED (GB) | 1992-06-09 | — | — | US | disclosed |
| US-5013749-A | Imidazole derivatives and their use as hypercholesterolemia and hyperlipoproteinemia agents | GLAXO GROUP LIMITED (GB) | 1991-05-07 | — | — | US | disclosed |
| US-4906659-A | Antibiotic tan-749, its derivatives, production and use thereof | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1990-03-06 | — | — | US | disclosed |
| EP-0271829-A2 | Delta-hydroxy-beta-lysine derivatives and their production | Takeda Chemical Industries, Ltd. (JP) | 1988-06-22 | — | — | EP | disclosed |
| US-4525582-A | Silyl, benzyl, p-nitrobenyl, or methyl esters of diazoacetate, a synthon used in the conversion of penicillin to thienamycin | MERCK & CO., INC. (US) | 1985-06-25 | — | — | US | disclosed |
| US-4444685-A | Stereospecific synthesis of thienamycin from penicillin | MERCK & CO., INC. (US) | 1984-04-24 | — | — | US | disclosed |