Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | F13A1 | P00488 | 1/20 | 0.45 |
| ▸ | TGM2 | P21980 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 3/20 | 0.44 |
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ENPP3 | O14638 | 3/20 | 0.41 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.40 |
| ▸ | FNTA | P49354 | 1/20 | 0.40 |
| ▸ | FNTB | P49356 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1375039 | 1.00 | EPHX2 (0.48) | EPHX2F13A1TGM2MMP13MMP2 | |
| SCHEMBL1372130 | 1.00 | EPHX2 (0.48) | EPHX2F13A1TGM2MMP13MMP2 | |
| SCHEMBL1373852 | 1.00 | EPHX2 (0.48) | EPHX2F13A1TGM2MMP13MMP2 | |
| SCHEMBL30726031 | 0.92 | ALDH1A1 (0.46) | HDAC8ALDH1A1GAAPOLB | |
| SCHEMBL1373800 | 0.84 | EPHX2 (0.48) | EPHX2F13A1TGM2MMP13MMP2 | |
| SCHEMBL3129745 | 0.83 | EPHX2 (0.45) | EPHX2F13A1TGM2MMP13MMP2 | |
| SCHEMBL1373946 | 0.82 | S1PR1 (0.52) | EPHX2F13A1TGM2MMP13MMP2 | |
| SCHEMBL1372387 | 0.82 | S1PR1 (0.51) | EPHX2F13A1TGM2MMP13MMP2 | |
| SCHEMBL2170273 | 0.82 | S1PR1 (0.51) | EPHX2F13A1TGM2MMP13MMP2 | |
| SCHEMBL2355325 | 0.81 | HRH3 (0.47) | EPHX2F13A1TGM2MMP13POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346821-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | Exelixis, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |