Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.45 |
| ▸ | MTOR | P42345 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.43 |
| ▸ | ACACB | O00763 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30664043 | 0.94 | CYP3A4 (0.47) | CYP11B2PIK3CAMTORCYP3A4ALDH1A1 | |
| SCHEMBL18291310 | 0.94 | CYP3A4 (0.47) | CYP11B2PIK3CAMTORCYP3A4ALDH1A1 | |
| SCHEMBL20255202 | 0.93 | CYP11B2 (0.48) | CYP11B2PIK3CAMTORCYP3A4CYP2C19 | |
| SCHEMBL25885002 | 0.93 | CYP11B2 (0.56) | CYP11B2PIK3CAMTORALDH1A1HDAC2 | |
| SCHEMBL30484800 | 0.93 | CYP11B2 (0.56) | CYP11B2PIK3CAMTORALDH1A1HDAC2 | |
| SCHEMBL31006174 | 0.93 | CYP11B2 (0.47) | CYP11B2PIK3CAMTORCYP3A4ALDH1A1 | |
| SCHEMBL19021793 | 0.93 | CYP11B2 (0.47) | CYP11B2PIK3CAMTORCYP3A4ALDH1A1 | |
| SCHEMBL18291321 | 0.91 | CYP11B2 (0.51) | CYP11B2PIK3CAMTORCYP3A4ALDH1A1 | |
| SCHEMBL30484809 | 0.90 | CYP11B2 (0.49) | CYP11B2PIK3CAMTORALDH1A1HDAC2 | |
| SCHEMBL15174881 | 0.90 | CYP11B2 (0.49) | CYP11B2PIK3CAMTORALDH1A1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3608321-A1 | 1H-IMIDAZO[4,5-H]QUINAZOLINE COMPOUND AS PROTEIN KINASE INHIBITOR | Shengke Pharmaceuticals (Jiangsu) Ltd. (CN) | 2020-02-12 | — | — | EP | disclosed |