Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
| ▸ | F2 | P00734 | 1/20 | 0.30 |
| ▸ | PLAT | P00750 | 1/20 | 0.30 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.30 |
| ▸ | BRAF | P15056 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21344816 | 0.81 | PPARG (0.37) | — | |
| SCHEMBL18681790 | 0.80 | KDM4E (0.39) | ALDH1A1MAPT | |
| SCHEMBL21343776 | 0.79 | ALDH1A1 (0.40) | ALDH1A1GAAMAPT | |
| SCHEMBL21343763 | 0.78 | HTR2A (0.35) | ALDH1A1GAAMAPTHSD17B10HTR2A | |
| SCHEMBL22894799 | 0.78 | HTR2A (0.37) | ALDH1A1GAAMAPTHSD17B10HTR2A | |
| SCHEMBL18468805 | 0.77 | KDM4E (0.48) | ALDH1A1MAPTNOTUM | |
| SCHEMBL18468811 | 0.75 | ALDH1A1 (0.39) | ALDH1A1MAPT | |
| SCHEMBL22640204 | 0.75 | PPARG (0.43) | ALDH1A1GAAMAPTHSD17B10 | |
| SCHEMBL22992867 | 0.74 | HTR2A (0.33) | ALDH1A1GAAMAPTHSD17B10HTR2A | |
| SCHEMBL21994011 | 0.74 | CA12 (0.49) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3424931-B1 | TETRAHYDRONAPHTHALENE DERIVATIVES THAT INHIBIT MCL-1 PROTEIN | AMGEN INC (US) | 2020-02-12 | — | — | EP | disclosed |