Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.49 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | CDC25A | P30304 | 1/20 | 0.38 |
| ▸ | CDC25B | P30305 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15434305 | 0.89 | EPHX1 (0.58) | EPHX1APPHTTALDH1A1GRM7 | |
| SCHEMBL2055564 | 0.89 | EPHX1 (0.58) | EPHX1APPHTTALDH1A1GRM7 | |
| SCHEMBL2170990 | 0.79 | EPHX1 (0.49) | EPHX1ALDH1A1 | |
| SCHEMBL5677024 | 0.78 | EPHX1 (0.55) | EPHX1APPALDH1A1 | |
| SCHEMBL22159114 | 0.76 | MEN1 (0.46) | MEN1KMT2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8427950 | 0.74 | GRM7 (0.45) | MEN1KMT2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8427951 | 0.74 | GRM7 (0.45) | MEN1KMT2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8427952 | 0.74 | GRM7 (0.45) | MEN1KMT2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL23003791 | 0.73 | GRM7 (0.47) | KMT2AHTTALDH1A1GRM7L3MBTL1 | |
| SCHEMBL11469527 | 0.72 | APP (0.49) | CYP1A2CYP2C9EPHX1APPMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346821-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | Exelixis, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |