Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 16/20 | 0.46 |
| ▸ | FPR2 | P25090 | 7/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SCN4A | P35499 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2055564 | 0.89 | EPHX1 (0.58) | EPHX1ALDH1A1 | |
| SCHEMBL15434305 | 0.89 | EPHX1 (0.58) | EPHX1ALDH1A1 | |
| SCHEMBL2169718 | 0.84 | PARP10 (0.58) | EPHX1 | |
| SCHEMBL2172240 | 0.84 | EPHX1 (0.50) | EPHX1ALDH1A1 | |
| SCHEMBL2173030 | 0.84 | PARP10 (0.55) | EPHX1 | |
| SCHEMBL11651502 | 0.83 | PARP10 (0.61) | EPHX1ALDH1A1 | |
| SCHEMBL2171656 | 0.83 | EPHX1 (0.49) | EPHX1ALDH1A1 | |
| SCHEMBL2170065 | 0.79 | MEN1 (0.51) | EPHX1ALDH1A1 | |
| SCHEMBL12886808 | 0.79 | SCN9A (0.47) | SCN9AFPR2ALDH1A1SCN4A | |
| SCHEMBL29457068 | 0.79 | SCN9A (0.45) | SCN9AFPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349252-A2 | SYNERGISTIC COMBINATION OF SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS AND ANTIMICROTUBULE AGENTS | Exelixis, Inc. (US) | 2011-08-03 | — | — | EP | disclosed |
| EP-2346821-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | Exelixis, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010045580-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | EXELIXIS, INC. (US) | 2010-04-22 | — | — | WO | disclosed |
| WO-2010045601-A2 | SYNERGISTIC EFFECTS BETWEEN SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS AND ANTIMICROTUBULE AGENTS | EXELIXIS, INC. (US) | 2010-04-22 | — | — | WO | disclosed |