Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | F10 | P00742 | 10/20 | 0.54 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21701458 | 0.92 | MAPT (0.54) | POLBMAPTKMT2AGAAF10 | |
| SCHEMBL21701410 | 0.90 | POLB (0.57) | POLBMAPTKMT2AGAAF10 | |
| SCHEMBL21701456 | 0.90 | POLB (0.57) | POLBMAPTKMT2AGAAF10 | |
| SCHEMBL21701415 | 0.90 | POLB (0.67) | POLBMAPTKMT2AF10CA1 | |
| SCHEMBL21701425 | 0.88 | POLB (0.55) | POLBMAPTKMT2AGAAF10 | |
| SCHEMBL21682947 | 0.88 | SERPINE1 (0.59) | POLBMAPTKMT2AF10MALT1 | |
| SCHEMBL21701424 | 0.88 | GAA (0.59) | POLBMAPTKMT2AGAAF10 | |
| SCHEMBL21701412 | 0.86 | KMT2A (0.55) | POLBMAPTKMT2AGAAF10 | |
| SCHEMBL21701605 | 0.83 | MAPT (0.57) | POLBMAPTKMT2AF10NPC1 | |
| SCHEMBL21701427 | 0.83 | MAPT (0.57) | POLBMAPTF10NPC1KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020033944-A2 | NON-POLYAMINE BASED POLYAMINE TRANSPORT INHIBITORS AND THEIR USE IN THE TREATMENT OF HUMAN CANCERS | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2020-02-13 | — | — | WO | disclosed |