Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | F10 | P00742 | 10/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21701456 | 0.90 | POLB (0.57) | POLBMAPTKMT2AGAAF10 | |
| SCHEMBL21701410 | 0.88 | POLB (0.57) | POLBMAPTKMT2AGAAF10 | |
| SCHEMBL21701423 | 0.88 | POLB (0.57) | POLBMAPTKMT2AGAAF10 | |
| SCHEMBL21701415 | 0.87 | POLB (0.67) | POLBMAPTKMT2AF10MEN1 | |
| SCHEMBL21701412 | 0.85 | KMT2A (0.55) | POLBMAPTKMT2AGAAF10 | |
| SCHEMBL21701424 | 0.85 | GAA (0.59) | POLBMAPTKMT2AGAAF10 | |
| SCHEMBL21701458 | 0.84 | MAPT (0.54) | POLBMAPTKMT2AGAAF10 | |
| SCHEMBL21682947 | 0.81 | SERPINE1 (0.59) | POLBMAPTKMT2AF10MEN1 | |
| SCHEMBL21701427 | 0.81 | MAPT (0.57) | POLBMAPTF10SERPINE1 | |
| SCHEMBL21701605 | 0.81 | MAPT (0.57) | POLBMAPTKMT2AF10SERPINE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020033944-A2 | NON-POLYAMINE BASED POLYAMINE TRANSPORT INHIBITORS AND THEIR USE IN THE TREATMENT OF HUMAN CANCERS | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2020-02-13 | — | — | WO | disclosed |