Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 13/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.52 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.51 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21701605 | 0.97 | MAPT (0.57) | F10MAPTPOLBSERPINE1KEAP1 | |
| SCHEMBL21701594 | 0.90 | F10 (0.57) | F10MAPTPOLBSERPINE1KEAP1 | |
| SCHEMBL21701581 | 0.87 | POLB (0.56) | F10MAPTPOLBRAB9AKMT2A | |
| SCHEMBL21701415 | 0.86 | POLB (0.67) | F10MAPTPOLBSERPINE1RAB9A | |
| SCHEMBL21701421 | 0.85 | MAPT (0.53) | F10MAPTPOLBSERPINE1KEAP1 | |
| SCHEMBL21701426 | 0.85 | F10 (0.61) | F10MAPTPOLBSERPINE1KEAP1 | |
| SCHEMBL21701424 | 0.84 | GAA (0.59) | F10MAPTPOLBSERPINE1KEAP1 | |
| SCHEMBL21701455 | 0.82 | MAPT (0.57) | F10MAPTPOLBSERPINE1KEAP1 | |
| SCHEMBL21701427 | 0.82 | MAPT (0.57) | F10MAPTPOLBSERPINE1KEAP1 | |
| SCHEMBL21701410 | 0.81 | POLB (0.57) | F10MAPTPOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020033944-A2 | NON-POLYAMINE BASED POLYAMINE TRANSPORT INHIBITORS AND THEIR USE IN THE TREATMENT OF HUMAN CANCERS | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2020-02-13 | — | — | WO | disclosed |