Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | F10 | P00742 | 10/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.51 |
| ▸ | CA9 | Q16790 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21701594 | 0.97 | F10 (0.57) | POLBALDH1A1MAPTCYP2C9SMN1; SMN2 | |
| SCHEMBL21701605 | 0.89 | MAPT (0.57) | POLBMAPTF10NPC1RAB9A | |
| SCHEMBL21701415 | 0.88 | POLB (0.67) | POLBALDH1A1MAPTL3MBTL1F10 | |
| SCHEMBL21701494 | 0.87 | F10 (0.59) | POLBALDH1A1MAPTF10RAB9A | |
| SCHEMBL21683033 | 0.86 | ALDH1A1 (0.57) | ALDH1A1MAPTCYP2C9SMN1; SMN2CYP1A2 | |
| SCHEMBL21701421 | 0.85 | MAPT (0.53) | POLBALDH1A1MAPTL3MBTL1F10 | |
| SCHEMBL21771103 | 0.83 | RAB9A (0.68) | ALDH1A1MAPTCYP2C9SMN1; SMN2L3MBTL1 | |
| SCHEMBL31504246 | 0.83 | RAB9A (0.68) | ALDH1A1MAPTCYP2C9SMN1; SMN2L3MBTL1 | |
| SCHEMBL21701456 | 0.83 | POLB (0.57) | POLBMAPTL3MBTL1F10KMT2A | |
| SCHEMBL21701423 | 0.83 | POLB (0.57) | POLBALDH1A1MAPTSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020033944-A2 | NON-POLYAMINE BASED POLYAMINE TRANSPORT INHIBITORS AND THEIR USE IN THE TREATMENT OF HUMAN CANCERS | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2020-02-13 | — | — | WO | disclosed |