Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PON1 | P27169 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.46 |
| ▸ | PLAUR | Q03405 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21685451 | 0.83 | DRD4 (0.40) | HTTDRD4ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL25939356 | 0.80 | MAP4K1 (0.49) | HTTHPGDDDAH1POLBPON1 | |
| SCHEMBL21703026 | 0.75 | MAP4K1 (0.50) | KDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL23453061 | 0.74 | MAP4K1 (0.39) | POLBGAAMAPT | |
| SCHEMBL21703024 | 0.74 | MAP4K1 (0.37) | KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL21703236 | 0.74 | ELANE (0.33) | GAAMAPTNPSR1 | |
| SCHEMBL16812412 | 0.74 | KDM4E (0.50) | HPGDPOLBNPC1RAB9APLAUR | |
| SCHEMBL23452764 | 0.74 | MAP4K1 (0.42) | HPGDKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL23453060 | 0.74 | MAP4K1 (0.38) | HTTHPGDPOLBGAAKDM4E | |
| SCHEMBL21703008 | 0.74 | MAP4K1 (0.40) | POLBGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219460-A1 | TRANSGLUTAMINASE 2 (TG2) INHIBITORS | Sitari Pharma, Inc. (US) | 2023-08-02 | — | — | EP | disclosed |
| WO-2020033784-A1 | TRANSGLUTAMINASE 2 (TG2) INHIBITORS | SITARI PHARMA, INC. (US) | 2020-02-13 | — | — | WO | disclosed |