Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 10/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | GNRHR | P30968 | 1/20 | 0.33 |
| ▸ | ATP4A | P20648 | 1/20 | 0.32 |
| ▸ | ATP4B | P51164 | 1/20 | 0.32 |
| ▸ | TERT | O14746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21703026 | 0.87 | MAP4K1 (0.50) | MAP4K1ELANEMAPTCHEK1ATP4A | |
| SCHEMBL23453061 | 0.83 | MAP4K1 (0.39) | MAP4K1ELANEMEN1POLBGAA | |
| SCHEMBL21703001 | 0.81 | MAP4K1 (0.42) | MAP4K1ELANECHEK1ATP4AATP4B | |
| SCHEMBL21685676 | 0.79 | MAP4K1 (0.40) | MAP4K1ELANEMEN1POLBGAA | |
| SCHEMBL21685880 | 0.77 | MAP4K1 (0.42) | MAP4K1ELANEMEN1POLBGAA | |
| SCHEMBL25942729 | 0.77 | MAP4K1 (0.50) | MAP4K1 | |
| SCHEMBL21685548 | 0.77 | MAP4K1 (0.43) | MAP4K1ELANEMEN1POLBGAA | |
| SCHEMBL21703004 | 0.76 | DHFR (0.44) | MAP4K1MEN1POLBKMT2A | |
| SCHEMBL23452764 | 0.76 | MAP4K1 (0.42) | MAP4K1ELANECHEK1 | |
| SCHEMBL23453060 | 0.76 | MAP4K1 (0.38) | MAP4K1ELANEMEN1POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219460-A1 | TRANSGLUTAMINASE 2 (TG2) INHIBITORS | Sitari Pharma, Inc. (US) | 2023-08-02 | — | — | EP | disclosed |
| WO-2020033784-A1 | TRANSGLUTAMINASE 2 (TG2) INHIBITORS | SITARI PHARMA, INC. (US) | 2020-02-13 | — | — | WO | disclosed |