Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.50 |
| ▸ | PARP1 | P09874 | 4/20 | 0.45 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25944744 | 0.83 | MAP4K1 (0.56) | MAP4K1PARP1PTGER3ALDH1A1 | |
| SCHEMBL21685182 | 0.81 | MAP4K1 (0.38) | MAP4K1PARP1ELANE | |
| SCHEMBL21703024 | 0.79 | MAP4K1 (0.37) | MAP4K1PARP1ELANEGABRA1GABRB2 | |
| SCHEMBL25944728 | 0.75 | MAP4K1 (0.59) | MAP4K1PTGER3KDM4EALDH1A1 | |
| SCHEMBL21703026 | 0.75 | MAP4K1 (0.50) | MAP4K1PARP1ELANEKDM4EALDH1A1 | |
| SCHEMBL21703398 | 0.74 | MAP4K1 (0.38) | MAP4K1PARP1ELANE | |
| SCHEMBL25944756 | 0.73 | MAP4K1 (0.57) | MAP4K1PTGER3KDM4EALDH1A1 | |
| SCHEMBL21703383 | 0.73 | MAP4K1 (0.34) | MAP4K1ELANEALDH1A1 | |
| SCHEMBL21685133 | 0.72 | MAP4K1 (0.41) | MAP4K1PARP1ELANEKDM4EALDH1A1 | |
| SCHEMBL25952900 | 0.72 | MAP4K1 (0.51) | MAP4K1PARP1ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020033784-A1 | TRANSGLUTAMINASE 2 (TG2) INHIBITORS | SITARI PHARMA, INC. (US) | 2020-02-13 | — | — | WO | disclosed |