Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | MIF | P14174 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28271036 | 0.84 | NPC1 (0.74) | NPC1L3MBTL1CASP3SENP8SENP7 | |
| SCHEMBL23599072 | 0.79 | NPC1 (0.62) | NPC1L3MBTL1CASP3SENP8SENP7 | |
| SCHEMBL5470573 | 0.77 | NPC1 (0.63) | NPC1L3MBTL1CASP3SENP8SENP7 | |
| SCHEMBL31175948 | 0.76 | NPC1 (0.62) | NPC1L3MBTL1CASP3SENP8SENP7 | |
| SCHEMBL13818451 | 0.76 | NPC1 (0.62) | NPC1L3MBTL1CASP3SENP8SENP7 | |
| SCHEMBL731645 | 0.76 | NPC1 (0.62) | NPC1L3MBTL1CASP3SENP8SENP7 | |
| SCHEMBL807820 | 0.76 | NPC1 (0.62) | NPC1L3MBTL1CASP3SENP8SENP7 | |
| SCHEMBL3832405 | 0.76 | NPC1 (0.62) | NPC1L3MBTL1CASP3SENP8SENP7 | |
| SCHEMBL21173257 | 0.73 | NPC1 (0.59) | NPC1L3MBTL1CASP3SENP8SENP7 | |
| SCHEMBL13985938 | 0.72 | NPC1 (0.68) | NPC1L3MBTL1CASP3SENP8SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200048289-A1 | PROCESS FOR PREPARING ORTHO-METALLATED METAL COMPOUNDS | MERCK PATENT GMBH (DE) | 2020-02-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200048289-A1 | PROCESS FOR PREPARING ORTHO-METALLATED METAL COMPOUNDS | NISCH, SOD1, MDM4 | NPC1 4206/4885L3MBTL1 2290/4885CASP3 3886/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.