SCHEMBL2170567

SCHEMBL2170567

Cc1cc(Cc2noc(C(F)(F)C(F)(F)F)n2)ccc1N

nearest known ligand 0.36

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
SKP2 Q13309 1/20 0.36
MAPK1 P28482 4/20 0.34
L3MBTL1 Q9Y468 4/20 0.34
SMN1; SMN2 Q16637 3/20 0.34
TDP1 Q9NUW8 2/20 0.34
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
LMNA P02545 3/20 0.34
TSHR P16473 2/20 0.32
KMT2A Q03164 5/20 0.32
MEN1 O00255 4/20 0.32
MAPT P10636 1/20 0.32
KLKB1 P03952 1/20 0.31
S100B P04271 1/20 0.31
POLB P06746 1/20 0.31
HPGD P15428 1/20 0.31
HTT P42858 1/20 0.31
HDAC4 P56524 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1833339 0.93 SKP2 (0.35) SKP2MAPK1L3MBTL1SMN1; SMN2TDP1
SCHEMBL1836487 0.80 NPC1 (0.38) MAPK1TDP1NPC1RAB9ATSHR
SCHEMBL1830252 0.79 SKP2 (0.40) SKP2SMN1; SMN2TDP1RAB9ALMNA
SCHEMBL1850589 0.76 S1PR1 (0.44) MAPK1L3MBTL1SMN1; SMN2TDP1NPC1
SCHEMBL2161183 0.75 SKP2 (0.37) SKP2TDP1TSHRKMT2AMEN1
SCHEMBL2161399 0.73 NPC1 (0.37) MAPK1TDP1NPC1RAB9ATSHR
SCHEMBL2161509 0.73 POLB (0.43) SMN1; SMN2NPC1RAB9ATSHRKMT2A
SCHEMBL1826287 0.72 SKP2 (0.41) SKP2TDP1RAB9ATSHRKMT2A
SCHEMBL1828505 0.71 SKP2 (0.35) SKP2KMT2AMEN1S100BHTT
SCHEMBL1831014 0.71 SKP2 (0.33) SKP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110184188-A1 Insecticidal Benzenedicarboxamide Derivative BAYER CROPSCIENCE AG (DE) 2011-07-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110184188-A1 Insecticidal Benzenedicarboxamide Derivative DDT, BRD9, BCL2A1 SKP2 2201/4885MAPK1 4164/4885L3MBTL1 217/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.