Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PNLIP | P16233 | 2/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | XIAP | P98170 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.42 |
| ▸ | PARG | Q86W56 | 1/20 | 0.42 |
| ▸ | STK39 | Q9UEW8 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2171467 | 0.89 | FFAR1 (0.57) | FFAR1PNLIPAPPSTK39ACACB | |
| SCHEMBL2736379 | 0.81 | FFAR1 (0.49) | FFAR1PNLIPMRGPRX4PARGSTK39 | |
| SCHEMBL2173030 | 0.79 | PARP10 (0.55) | FFAR1PTGS1LMNAL3MBTL1MEN1 | |
| SCHEMBL7032448 | 0.78 | PTGS1 (0.77) | FFAR1PTGS1LMNAL3MBTL1MEN1 | |
| SCHEMBL7040469 | 0.78 | PTGS1 (0.77) | FFAR1PTGS1LMNAL3MBTL1MEN1 | |
| SCHEMBL28775716 | 0.75 | APP (0.55) | PTGS1LMNAMEN1KMT2AAKR1C3 | |
| SCHEMBL5673527 | 0.75 | APP (0.53) | PTGS1LMNAAKR1C3AKR1C2APP | |
| SCHEMBL5673531 | 0.75 | APP (0.53) | PTGS1LMNAAKR1C3AKR1C2APP | |
| SCHEMBL30002874 | 0.75 | APP (0.53) | PTGS1LMNAAKR1C3AKR1C2APP | |
| SCHEMBL27486876 | 0.75 | PARP10 (0.59) | LMNAPNLIPMRGPRX4KMT2ACTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346821-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | Exelixis, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010045580-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | EXELIXIS, INC. (US) | 2010-04-22 | — | — | WO | disclosed |