SCHEMBL21708099

SCHEMBL21708099

N#Cc1cnc2sc(CC(F)(F)F)cc2c1Cl

nearest known ligand 0.43

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 20/20 0.43
KMT2A Q03164 14/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3999968 0.82 SELE (0.51) MEN1KMT2A
SCHEMBL21427134 0.79 MEN1 (0.41) MEN1KMT2A
SCHEMBL21427131 0.79 MEN1 (0.40) MEN1KMT2A
SCHEMBL22926960 0.78 MEN1 (0.43) MEN1KMT2A
SCHEMBL3995602 0.76 ADORA1 (0.45)
SCHEMBL4947940 0.76 CSNK1A1 (0.36)
SCHEMBL22926964 0.76 MEN1 (0.40) MEN1KMT2A
SCHEMBL22926974 0.75 MEN1 (0.53) MEN1KMT2A
SCHEMBL3993667 0.74 CSNK1A1 (0.34)
SCHEMBL3992555 0.74 CSNK1A1 (0.34) MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11325921-B2 Optically active crosslinked cyclic secondary amine derivative SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) 2022-05-10 US disclosed
US-11325921-B2 Optically active crosslinked cyclic secondary amine derivative SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) 2022-05-10 US disclosed
US-20210198283-A1 OPTICALLY ACTIVE BRIDGED PIPERIDINE DERIVATIVE SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) 2021-07-01 US disclosed
US-20210198283-A1 OPTICALLY ACTIVE BRIDGED PIPERIDINE DERIVATIVE SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) 2021-07-01 US disclosed
EP-3835304-A1 OPTICALLY ACTIVE BRIDGED PIPERIDINE DERIVATIVE Sumitomo Dainippon Pharma Co., Ltd. (JP) 2021-06-16 EP disclosed
EP-3835304-A1 OPTICALLY ACTIVE BRIDGED PIPERIDINE DERIVATIVE Sumitomo Dainippon Pharma Co., Ltd. (JP) 2021-06-16 EP disclosed
US-20210024547-A1 OPTICALLY ACTIVE CROSSLINKED CYCLIC SECONDARY AMINE DERIVATIVE SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) 2021-01-28 US disclosed
US-20210024547-A1 OPTICALLY ACTIVE CROSSLINKED CYCLIC SECONDARY AMINE DERIVATIVE SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) 2021-01-28 US disclosed
WO-2020032105-A1 OPTICALLY ACTIVE BRIDGED PIPERIDINE DERIVATIVE 大日本住友製薬株式会社 2020-02-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210024547-A1 OPTICALLY ACTIVE CROSSLINKED CYCLIC SECONDARY AMINE DERIVATIVE MLLT3, MEN1, MLLT1 MEN1 2/4885KMT2A 32/4885
US-20210198283-A1 OPTICALLY ACTIVE BRIDGED PIPERIDINE DERIVATIVE MLLT3, MLLT1, MEN1 MEN1 3/4885KMT2A 92/4885
US-11325921-B2 Optically active crosslinked cyclic secondary amine derivative MLLT3, MEN1, MLLT1 MEN1 2/4885KMT2A 32/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.