Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 7/20 | 0.53 |
| ▸ | RAB9A | P51151 | 6/20 | 0.52 |
| ▸ | NPC1 | O15118 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | CNR1 | P21554 | 2/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1093851 | 0.83 | ADORA3 (0.57) | SMN1; SMN2CNR1CNR2HTTADORA3 | |
| SCHEMBL15387546 | 0.83 | KCNJ6 (0.45) | RAB9ANPC1CNR1CNR2MEN1 | |
| SCHEMBL1093673 | 0.79 | ADORA3 (0.53) | RAB9ANPC1SMN1; SMN2CNR1CNR2 | |
| SCHEMBL2349507 | 0.79 | NR1H4 (0.49) | CYP2C9CNR1CNR2MEN1KMT2A | |
| SCHEMBL1093936 | 0.77 | CNR1 (0.46) | EPHX1ALDH1A1CNR1CNR2MEN1 | |
| SCHEMBL1094213 | 0.76 | CNR1 (0.45) | EPHX1ALDH1A1CNR1CNR2MEN1 | |
| SCHEMBL1093283 | 0.76 | CNR1 (0.44) | EPHX1ALDH1A1CNR1CNR2MEN1 | |
| SCHEMBL1093879 | 0.75 | CNR1 (0.43) | EPHX1SMN1; SMN2ALDH1A1CNR1CNR2 | |
| SCHEMBL1712321 | 0.75 | ESR2 (0.47) | RAB9ANPC1SMN1; SMN2ALDH1A1CNR1 | |
| SCHEMBL1712590 | 0.74 | NR1H4 (0.46) | CYP2C9CNR1CNR2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346834-A1 | 3-AMINO-INDAZOLE OR 3-AMINO-4,5,6,7-TETRAHYDRO-INDAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010034657-A1 | 3-AMINO-INDAZOLE OR 3-AMINO-4,5,6,7-TETRAHYDRO-INDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-04-01 | — | — | WO | disclosed |