Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 12/20 | 0.43 |
| ▸ | TP53 | P04637 | 10/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA3 | P07451 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA6 | P23280 | 1/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL661086 | 0.91 | MDM2 (0.49) | MDM2TP53LMNACA12CA1 | |
| SCHEMBL662529 | 0.89 | LMNA (0.45) | LMNACA12CA1CA2CA3 | |
| SCHEMBL659952 | 0.85 | LMNA (0.47) | MDM2TP53LMNACA12CA1 | |
| SCHEMBL662402 | 0.84 | MDM2 (0.48) | MDM2TP53LMNACA12CA1 | |
| SCHEMBL661326 | 0.83 | LMNA (0.49) | LMNACA12CA1CA2CA3 | |
| SCHEMBL660614 | 0.82 | LMNA (0.50) | LMNACA12CA1CA2CA3 | |
| SCHEMBL564465 | 0.81 | MDM2 (0.44) | MDM2TP53LMNACA12CA1 | |
| SCHEMBL563707 | 0.79 | LMNA (0.41) | LMNACA12CA1CA2CA3 | |
| SCHEMBL19732581 | 0.79 | LMNA (0.41) | LMNACA12CA1CA2CA3 | |
| SCHEMBL661084 | 0.78 | SRD5A1 (0.52) | LMNACA12CA1CA2CA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3610890-A1 | METHODS AND COMPOSITIONS FOR TREATING SCHIZOPHRENIA | The Johns Hopkins University (US) | 2020-02-19 | — | — | EP | disclosed |