⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25127409 | 0.76 | — | — | |
| SCHEMBL2171787 | 0.67 | CHRNB2 (0.30) | — | |
| SCHEMBL8946977 | 0.67 | — | — | |
| SCHEMBL2170868 | 0.62 | — | — | |
| SCHEMBL15726989 | 0.62 | — | — | |
| SCHEMBL13342475 | 0.62 | — | — | |
| SCHEMBL15090668 | 0.62 | — | — | |
| SCHEMBL22778538 | 0.62 | — | — | |
| SCHEMBL21744776 | 0.62 | — | — | |
| SCHEMBL19630923 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346507-A1 | USE OF QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF VIRAL DISEASES | Boehringer Ingelheim International GmbH (DE) | 2011-07-27 | — | — | EP | claimed |
| WO-2010026029-A1 | USE OF QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF VIRAL DISEASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-03-11 | — | — | WO | claimed |
| EP-0670310-B1 | Bisulfite adducts of arginine aldehydes useful as thrombin inhibitors and as anticoagulants | LILLY CO ELI (US) | 1998-09-02 | — | — | EP | claimed |
| US-5578574-A | THROMBIN INHIBITORS OR ANTICOAGULANTS | ELI LILLY AND COMPANY (US) | 1996-11-26 | — | — | US | claimed |
| EP-0672665-A1 | Antithrombotic agents | ELI LILLY AND COMPANY (US) | 1995-09-20 | — | — | EP | claimed |
| EP-0670310-A1 | Bisulfite adducts of arginine aldehydes useful as thrombin inhibitors and as anticoagulants | ELI LILLY AND COMPANY (US) | 1995-09-06 | — | — | EP | claimed |
| US-5436229-A | Di- and tripeptides as anticoagulants | ELI LILLY AND COMPANY (US) | 1995-07-25 | — | — | US | claimed |
| JP-7278092-A | — | — | None | — | — | JP | disclosed |
| JP-7278095-A | — | — | None | — | — | JP | disclosed |
| EP-0670310-B1 | Bisulfite adducts of arginine aldehydes useful as thrombin inhibitors and as anticoagulants | LILLY CO ELI (US) | 1998-09-02 | — | — | EP | disclosed |
| US-5578574-A | THROMBIN INHIBITORS OR ANTICOAGULANTS | ELI LILLY AND COMPANY (US) | 1996-11-26 | — | — | US | disclosed |
| JP-H07278092-A | ANTITHROMBOTIC AGENT | ELI LILLY & CO | 1995-10-24 | — | — | JP | disclosed |
| JP-H07278095-A | HYDROGENSULFITE ADDUCT OF ARGININE ALDEHYDE | ELI LILLY & CO | 1995-10-24 | — | — | JP | disclosed |
| EP-0672665-A1 | Antithrombotic agents | ELI LILLY AND COMPANY (US) | 1995-09-20 | — | — | EP | disclosed |
| EP-0670310-A1 | Bisulfite adducts of arginine aldehydes useful as thrombin inhibitors and as anticoagulants | ELI LILLY AND COMPANY (US) | 1995-09-06 | — | — | EP | disclosed |
| US-5436229-A | Di- and tripeptides as anticoagulants | ELI LILLY AND COMPANY (US) | 1995-07-25 | — | — | US | disclosed |