SCHEMBL21708859

SCHEMBL21708859

C#CCN(CC#C)CCc1ccc2c(c1)OC(C)(C)O2

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.43
CA1 P00915 1/20 0.43
CA2 P00918 1/20 0.43
CA4 P22748 1/20 0.43
CA9 Q16790 1/20 0.43
ALOX15 P16050 1/20 0.41
ALOX12 P18054 1/20 0.41
TSHR P16473 2/20 0.36
CYP3A4 P08684 1/20 0.35
CYP2D6 P10635 1/20 0.35
DRD2 P14416 1/20 0.35
NFKB1 P19838 1/20 0.35
DRD1 P21728 1/20 0.35
DRD4 P21917 1/20 0.35
DRD5 P21918 1/20 0.35
ADRA1D P25100 1/20 0.35
ADRA1A P35348 1/20 0.35
ADRA1B P35368 1/20 0.35
DRD3 P35462 1/20 0.35
HIF1A Q16665 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21708900 0.79 CA12 (0.35) CA12CA1CA2CA4CA9
SCHEMBL21708944 0.78 ALOX15 (0.36) ALOX15ALOX12CYP3A4CYP2D6ACHE
SCHEMBL21709141 0.76 TSHR (0.35) CA12CA1CA2CA4CA9
SCHEMBL21708850 0.75 ALOX15 (0.42) ALOX15ALOX12TSHRPYCR1ACHE
SCHEMBL9589157 0.73 ALOX15 (0.50) ALOX15ALOX12TSHR
SCHEMBL31490194 0.72 ALOX15 (0.53) CA2ALOX15ALOX12TSHRKDM4E
SCHEMBL11888425 0.72 TAAR1 (0.53) ALOX15ALOX12TSHRCYP3A4CYP2D6
SCHEMBL367973 0.72 ALOX15 (0.53) CA2ALOX15ALOX12TSHRKDM4E
SCHEMBL21708851 0.71 AOC3 (0.40) ALOX15ALOX12TSHRCYP2D6
SCHEMBL11630777 0.71 ALOX15 (0.51) ALOX15ALOX12TSHRKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020032080-A1 COMPOUND, SALT OF COMPOUND, NEUROMODULATION AGENT, METHOD FOR EVALUATING NEUROMODULATION AGENT, METHOD FOR PRODUCING COMPOUND, AND METHOD FOR PRODUCING SALT OF COMPOUND 学校法人慶應義塾 2020-02-13 WO disclosed