Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 18/20 | 0.52 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21711843 | 0.88 | WDR5 (0.49) | WDR5 | |
| SCHEMBL21711853 | 0.87 | KCNH2 (0.49) | WDR5GRM2 | |
| SCHEMBL21712089 | 0.87 | WDR5 (0.49) | WDR5GRM2 | |
| SCHEMBL21817631 | 0.83 | WDR5 (0.47) | WDR5 | |
| SCHEMBL21712078 | 0.80 | WDR5 (0.50) | WDR5 | |
| SCHEMBL3877931 | 0.79 | GRM2 (0.41) | GRM2CACNA1HCACNA1BCACNA1C | |
| SCHEMBL21711946 | 0.79 | KCNH2 (0.52) | WDR5GRM2 | |
| SCHEMBL21711976 | 0.78 | WDR5 (0.42) | WDR5 | |
| SCHEMBL21711886 | 0.78 | WDR5 (0.47) | WDR5GRM2 | |
| SCHEMBL21711962 | 0.78 | WDR5 (0.49) | WDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10807959-B2 | WDR5-MLL1 inhibitors and modulators | VANDERBILT UNIVERSITY (US) | 2020-10-20 | — | — | US | disclosed |
| US-20200055824-A1 | WDR5-MLL1 INHIBITORS AND MODULATORS | VANDERBILT UNIVERSITY | 2020-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10807959-B2 | WDR5-MLL1 inhibitors and modulators | WDR5, WDR1, WDR3 | WDR5 1/4885GRM2 1265/4885CACNA1H 4277/4885 |
| US-20200055824-A1 | WDR5-MLL1 INHIBITORS AND MODULATORS | WDR5, WDR1, WDR3 | WDR5 1/4885GRM2 1265/4885CACNA1H 4277/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.