Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 18/20 | 0.64 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21712024 | 0.92 | WDR5 (0.63) | WDR5EGLN1KDM4EUSP2ALDH1A1 | |
| SCHEMBL22750322 | 0.87 | WDR5 (0.72) | WDR5EGLN1KDM4EUSP2ALDH1A1 | |
| SCHEMBL21711926 | 0.87 | WDR5 (0.67) | WDR5EGLN1KDM4EUSP2ALDH1A1 | |
| SCHEMBL21711891 | 0.87 | WDR5 (0.72) | WDR5EGLN1KDM4EUSP2ALDH1A1 | |
| SCHEMBL29767292 | 0.83 | WDR5 (0.66) | WDR5 | |
| SCHEMBL21711831 | 0.79 | WDR5 (1.00) | WDR5 | |
| SCHEMBL21711709 | 0.78 | WDR5 (1.00) | WDR5 | |
| SCHEMBL21711617 | 0.75 | WDR5 (0.72) | WDR5 | |
| SCHEMBL21711703 | 0.74 | WDR5 (0.69) | WDR5 | |
| SCHEMBL21711870 | 0.74 | WDR5 (0.73) | WDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10807959-B2 | WDR5-MLL1 inhibitors and modulators | VANDERBILT UNIVERSITY (US) | 2020-10-20 | — | — | US | disclosed |
| US-20200055824-A1 | WDR5-MLL1 INHIBITORS AND MODULATORS | VANDERBILT UNIVERSITY | 2020-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10807959-B2 | WDR5-MLL1 inhibitors and modulators | WDR5, WDR1, WDR3 | WDR5 1/4885EGLN1 249/4885KDM4E 68/4885 |
| US-20200055824-A1 | WDR5-MLL1 INHIBITORS AND MODULATORS | WDR5, WDR1, WDR3 | WDR5 1/4885EGLN1 249/4885KDM4E 68/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.