Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.46 |
| ▸ | P2RX2 | Q9UBL9 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2171732 | 0.92 | NPC1 (0.53) | NPC1RAB9APOLBLMNAP2RX3 | |
| SCHEMBL2171537 | 0.91 | P2RX3 (0.51) | NPC1RAB9APOLBLMNAP2RX3 | |
| SCHEMBL2185262 | 0.89 | P2RX3 (0.51) | NPC1RAB9APOLBLMNAP2RX3 | |
| SCHEMBL2190640 | 0.85 | P2RX3 (0.49) | NPC1RAB9APOLBLMNAP2RX3 | |
| SCHEMBL2171928 | 0.83 | P2RX3 (0.51) | NPC1RAB9APOLBLMNAP2RX3 | |
| SCHEMBL2248955 | 0.82 | P2RX3 (0.46) | NPC1RAB9APOLBLMNAP2RX3 | |
| SCHEMBL2186317 | 0.82 | P2RX3 (0.49) | NPC1RAB9APOLBLMNAP2RX3 | |
| SCHEMBL2384206 | 0.81 | CYP1A2 (0.46) | P2RX3P2RX2 | |
| SCHEMBL2187881 | 0.81 | CYP1A2 (0.46) | P2RX3P2RX2 | |
| SCHEMBL16203107 | 0.80 | P2RX3 (0.56) | LMNAP2RX3P2RX2L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346825-A2 | MODULATORS OF P2X3 RECEPTOR ACTIVITY | Evotec AG (DE) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010033168-A2 | AMIDE COMPOUNDS, COMPOSITIONS AND USES THEREOF | RENOVIS, INC. (US) | 2010-03-25 | — | — | WO | disclosed |