Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | TP53 | P04637 | 7/20 | 0.67 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2547306 | 0.82 | MAPT (0.79) | POLBMAPTTP53NR1H4LMNA | |
| SCHEMBL2186610 | 0.78 | MAPT (0.72) | POLBMAPTTP53NPC1RAB9A | |
| SCHEMBL2547296 | 0.78 | MAPT (0.69) | POLBMAPTTP53NR1H4LMNA | |
| SCHEMBL2172878 | 0.76 | TP53 (0.68) | POLBMAPTTP53NR1H4LMNA | |
| SCHEMBL2171100 | 0.76 | MAPT (0.69) | POLBMAPTTP53NPC1RAB9A | |
| SCHEMBL2542966 | 0.74 | MAPT (0.70) | POLBMAPTTP53NPC1RAB9A | |
| SCHEMBL2542223 | 0.73 | MAPT (0.66) | POLBMAPTTP53TSHR | |
| SCHEMBL2174259 | 0.73 | MAPT (0.62) | POLBMAPTTP53NR1H4NPC1 | |
| SCHEMBL2546880 | 0.72 | POLB (0.64) | POLBMAPTTP53NR1H4NPC1 | |
| SCHEMBL2174453 | 0.72 | MAPT (0.64) | POLBMAPTTP53NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346832-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | Glaxo Group Limited (GB) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010049366-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2010-05-06 | — | — | WO | disclosed |