Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MIF | P14174 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5775887 | 0.80 | MEN1 (0.52) | MEN1KMT2ATSHRMAPK1HIF1A | |
| SCHEMBL9302742 | 0.77 | ESR1 (0.48) | MEN1KMT2ATSHRHIF1AHSD17B10 | |
| SCHEMBL1332508 | 0.77 | CYP2C9 (0.41) | KMT2ATSHRMAPK1HIF1ACYP2A6 | |
| SCHEMBL2860836 | 0.75 | TSHR (0.74) | MEN1KMT2ATSHRMAPK1HIF1A | |
| SCHEMBL3825948 | 0.75 | KCNN4 (0.46) | MEN1KMT2AMAPK1CYP19A1LMNA | |
| SCHEMBL30366430 | 0.73 | NPSR1 (0.47) | MEN1KMT2ATSHRMAPK1HIF1A | |
| SCHEMBL31634141 | 0.73 | MEN1 (0.45) | MEN1KMT2ATSHRMAPK1HIF1A | |
| SCHEMBL811710 | 0.73 | KMT2A (0.45) | MEN1KMT2ATSHRMAPK1HIF1A | |
| SCHEMBL10764412 | 0.73 | MEN1 (0.62) | MEN1KMT2ATSHRMAPK1HIF1A | |
| SCHEMBL7434539 | 0.73 | CYP19A1 (0.73) | MEN1KMT2ATSHRMAPK1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346872-A1 | AZOLOTRIAZINONE MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS | Bristol-Myers Squibb Company (US) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010042682-A1 | AZOLOTRIAZINONE MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-04-15 | — | — | WO | disclosed |