Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2B6 | P20813 | 1/20 | 0.44 |
| ▸ | CCR6 | P51684 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | PANK3 | Q9H999 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21566474 | 0.88 | CYP2B6 (0.51) | CYP2B6ALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL277165 | 0.82 | ALDH1A1 (0.54) | ALDH1A1LMNAMAPTKDM4EGAA | |
| SCHEMBL14923962 | 0.80 | PANK3 (0.43) | ALDH1A1LMNAMAPTKDM4EGAA | |
| SCHEMBL22006730 | 0.80 | ALDH1A1 (0.40) | ALDH1A1LMNAMAPTKDM4EGAA | |
| SCHEMBL18118180 | 0.80 | ALDH1A1 (0.57) | CCR6ALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL847809 | 0.80 | ALDH1A1 (0.57) | CCR6ALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL18118174 | 0.78 | HPGD (0.52) | ALDH1A1LMNAMAPTKDM4EGAA | |
| SCHEMBL20251137 | 0.78 | MAPT (0.51) | ALDH1A1LMNAMAPTKDM4EGAA | |
| SCHEMBL19273451 | 0.78 | CYP2B6 (0.41) | CYP2B6ALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL23544866 | 0.76 | PANK3 (0.46) | ALDH1A1LMNAMAPTKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10975084-B2 | KDM5 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2021-04-13 | — | — | US | disclosed |
| US-20200048258-A1 | KDM5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-02-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200048258-A1 | KDM5 INHIBITORS | KDM5A, KDM5B, KDM5C | CYP2B6 1838/4885CCR6 4414/4885ALDH1A1 1399/4885 |
| US-10975084-B2 | KDM5 inhibitors | KDM5A, KDM5B, KDM5C | CYP2B6 1838/4885CCR6 4414/4885ALDH1A1 1399/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.