Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KMO | O15229 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MYC | P01106 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | AGER | Q15109 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ASPH | Q12797 | 1/20 | 0.31 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.30 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL981000 | 0.73 | KMT2A (0.50) | KDM4EMAPTALDH1A1TSHRKMT2A | |
| SCHEMBL984761 | 0.72 | MCL1 (0.46) | KDM4EMAPTALDH1A1KMOKMT2A | |
| SCHEMBL2057011 | 0.71 | KMO (0.52) | KDM4EMAPTALDH1A1KMOKMT2A | |
| SCHEMBL2408116 | 0.70 | HCAR2 (0.43) | KDM4EMAPTALDH1A1KMOTSHR | |
| SCHEMBL3344838 | 0.70 | KDM4E (0.44) | KDM4EMAPTALDH1A1KMT2AASPH | |
| SCHEMBL1340669 | 0.70 | KDM4E (0.53) | KDM4EMAPTALDH1A1TSHRL3MBTL1 | |
| SCHEMBL3351611 | 0.69 | GRIN2B (0.43) | KDM4EKMOASPHKDM8 | |
| SCHEMBL24485255 | 0.68 | NAPRT (0.45) | KDM4EMAPTALDH1A1TSHRL3MBTL1 | |
| SCHEMBL10419666 | 0.67 | KDM4E (0.50) | KDM4EMAPTALDH1A1TSHRL3MBTL1 | |
| SCHEMBL5775106 | 0.66 | KMO (0.47) | KDM4EMAPTALDH1A1KMOTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3837250-A1 | PYRAZINE COMPOUNDS AND USES THEREOF | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD (CN) | 2021-06-23 | — | — | EP | disclosed |
| WO-2020035052-A1 | PYRAZINE COMPOUNDS AND USES THEREOF | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) | 2020-02-20 | — | — | WO | disclosed |