SCHEMBL21723237

SCHEMBL21723237

Cc1cc(F)c(-n2nc(C(F)(F)F)nc2N)cc1C(=O)O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TTR P02766 1/20 0.41
GABRP O00591 1/20 0.35
GABRD O14764 1/20 0.35
GABRA1 P14867 1/20 0.35
GABRB1 P18505 1/20 0.35
GABRG2 P18507 1/20 0.35
GABRB3 P28472 1/20 0.35
GABRA5 P31644 1/20 0.35
GABRA3 P34903 1/20 0.35
GABRA2 P47869 1/20 0.35
GABRB2 P47870 1/20 0.35
GABRA4 P48169 1/20 0.35
GABRE P78334 1/20 0.35
GABRA6 Q16445 1/20 0.35
GABRG1 Q8N1C3 1/20 0.35
GABRG3 Q99928 1/20 0.35
GABRQ Q9UN88 1/20 0.35
ALDH1A1 P00352 5/20 0.33
TSHR P16473 1/20 0.33
RXRA P19793 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21723198 0.88 TTR (0.42) TTRALDH1A1TSHRRXRARXRB
SCHEMBL21723234 0.86 TTR (0.38) TTRALDH1A1TSHRKMT2AKDM4E
SCHEMBL2920041 0.81 DHODH (0.33) DHODH
SCHEMBL21723180 0.81 TTR (0.41) TTRGABRPGABRDGABRA1GABRB1
Fluoride SCHEMBL27941631 0.79 BRD4 (0.30)
SCHEMBL2919911 0.78 PTGS2 (0.31) DHODH
SCHEMBL2917611 0.77 DHODH (0.30) DHODH
SCHEMBL21723610 0.77 TTR (0.44) TTRGABRPGABRDGABRA1GABRB1
SCHEMBL2921903 0.75 DHODH (0.30) DHODH
SCHEMBL27889303 0.74

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020036133-A1 3-(1H-1,2,4-TRIAZOLE-1-YL) BENZOIC ACID AMIDE DERIVATIVE AND HARMFUL ORGANISM CONTROL AGENT クミアイ化学工業株式会社 2020-02-20 WO disclosed