SCHEMBL21723239

SCHEMBL21723239

CCOC(=O)c1cc(-n2nc(C(F)(F)F)nc2N(C(C)=O)C(C)=O)c(F)cc1C

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.38
MAPT P10636 2/20 0.38
HTT P42858 1/20 0.38
JMJD6 Q6NYC1 1/20 0.37
FOS P01100 3/20 0.37
JUN P05412 3/20 0.37
NFKB1 P19838 3/20 0.37
NFKB2 Q00653 3/20 0.37
RELA Q04206 3/20 0.37
PPOX P50336 2/20 0.35
KDM4E B2RXH2 2/20 0.35
ALOX15 P16050 2/20 0.35
NPSR1 Q6W5P4 2/20 0.35
NPC1 O15118 1/20 0.35
TP53 P04637 1/20 0.35
RAB9A P51151 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
GAA P10253 1/20 0.35
KMT2A Q03164 1/20 0.35
LMNA P02545 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21723192 0.86 JMJD6 (0.40) ALDH1A1MAPTHTTJMJD6FOS
SCHEMBL21723244 0.73 JMJD6 (0.41) ALDH1A1MAPTHTTJMJD6KDM4E
SCHEMBL21723198 0.71 TTR (0.42) ALDH1A1HTTKDM4ESMN1; SMN2GAA
SCHEMBL21723595 0.70 KDM4E (0.36) ALDH1A1MAPTHTTJMJD6NFKB1
SCHEMBL21723252 0.69 JMJD6 (0.39) ALDH1A1MAPTHTTJMJD6ALOX15
SCHEMBL21723214 0.69 JMJD6 (0.39) ALDH1A1MAPTHTTJMJD6KDM4E
SCHEMBL21723237 0.69 TTR (0.41) ALDH1A1HTTKDM4ESMN1; SMN2GAA
SCHEMBL21723234 0.68 TTR (0.38) ALDH1A1HTTKDM4EKMT2ATSHR
SCHEMBL21723183 0.67 DHODH (0.33) P2RX7
SCHEMBL8133633 0.67 TSHR (0.52) ALDH1A1MAPTHTTJMJD6KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020036133-A1 3-(1H-1,2,4-TRIAZOLE-1-YL) BENZOIC ACID AMIDE DERIVATIVE AND HARMFUL ORGANISM CONTROL AGENT クミアイ化学工業株式会社 2020-02-20 WO disclosed