Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.42 |
| ▸ | CLK2 | P49760 | 5/20 | 0.36 |
| ▸ | TTK | P33981 | 5/20 | 0.36 |
| ▸ | CLK1 | P49759 | 4/20 | 0.36 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21723695 | 0.85 | DYRK1A (0.38) | LRRK2CLK2TTKCLK1CAMKK2 | |
| SCHEMBL28598005 | 0.84 | LRRK2 (0.55) | LRRK2CLK2TTKCLK1CAMKK2 | |
| SCHEMBL28593022 | 0.82 | LRRK2 (0.54) | LRRK2HSP90AA1HSP90AB1KDM4EALDH1A1 | |
| SCHEMBL29126151 | 0.80 | HSP90AA1 (0.40) | LRRK2HSP90AA1HSP90AB1EGFRKDM4E | |
| SCHEMBL29126098 | 0.74 | LRRK2 (0.40) | LRRK2CLK2TTKCLK1CAMKK2 | |
| SCHEMBL21738312 | 0.74 | LRRK2 (0.78) | LRRK2TTK | |
| SCHEMBL29126132 | 0.73 | EGFR (0.38) | LRRK2CLK2TTKCLK1CAMKK2 | |
| SCHEMBL21723706 | 0.72 | LRRK2 (0.47) | LRRK2EGFR | |
| SCHEMBL21738325 | 0.71 | LRRK2 (0.73) | LRRK2TTK | |
| SCHEMBL21738251 | 0.71 | LRRK2 (0.70) | LRRK2CLK2TTKCLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020036437-A1 | SUBSTITUTED HETEROARYL DERIVATIVE, METHOD FOR PRODUCING SAME, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING PROTEIN KINASE-RELATED DISEASES WHICH CONTAINS SAME AS ACTIVE INGREDIENT | 재단법인 대구경북첨단의료산업진흥재단 | 2020-02-20 | — | — | WO | claimed |
| WO-2020036437-A1 | SUBSTITUTED HETEROARYL DERIVATIVE, METHOD FOR PRODUCING SAME, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING PROTEIN KINASE-RELATED DISEASES WHICH CONTAINS SAME AS ACTIVE INGREDIENT | 재단법인 대구경북첨단의료산업진흥재단 | 2020-02-20 | — | — | WO | disclosed |