Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 15/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14995754 | 0.85 | LRRK2 (0.67) | LRRK2 | |
| SCHEMBL25302280 | 0.84 | LRRK2 (0.50) | LRRK2ALK | |
| SCHEMBL2034102 | 0.83 | LRRK2 (0.58) | LRRK2ALKAURKAKDRTRPV1 | |
| SCHEMBL21723722 | 0.82 | LRRK2 (0.48) | LRRK2ALK | |
| SCHEMBL30242558 | 0.79 | LRRK2 (0.56) | LRRK2ALKAURKAKDRAURKB | |
| SCHEMBL10206179 | 0.79 | LRRK2 (0.56) | LRRK2ALK | |
| SCHEMBL28925066 | 0.78 | LRRK2 (0.58) | LRRK2 | |
| SCHEMBL14556210 | 0.78 | LRRK2 (0.51) | LRRK2ALK | |
| SCHEMBL27897413 | 0.77 | LRRK2 (0.57) | LRRK2 | |
| SCHEMBL21173791 | 0.77 | TTK (0.57) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020036437-A1 | SUBSTITUTED HETEROARYL DERIVATIVE, METHOD FOR PRODUCING SAME, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING PROTEIN KINASE-RELATED DISEASES WHICH CONTAINS SAME AS ACTIVE INGREDIENT | 재단법인 대구경북첨단의료산업진흥재단 | 2020-02-20 | — | — | WO | disclosed |