Sugi Predict

Sugi Predict / Compounds / SCHEMBL21723992

SCHEMBL21723992

SCHEMBL21723992

C#CC(=O)N(C)c1csc(-c2ccccc2)c1

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ HSD17B1 P14061 10/20 0.41
▸ HSD17B2 P37059 10/20 0.41
▸ CNR1 P21554 1/20 0.38
▸ ALOX15 P16050 1/20 0.36
▸ IKBKB O14920 1/20 0.35
▸ KDM4E B2RXH2 1/20 0.34
▸ LMNA P02545 1/20 0.34
▸ MAPT P10636 1/20 0.34
▸ PKM P14618 1/20 0.34
▸ RXFP1 Q9HBX9 1/20 0.34
▸ HTR3E A5X5Y0 1/20 0.33
▸ HTR3B O95264 1/20 0.33
▸ CHRNA7 P36544 1/20 0.33
▸ HTR3A P46098 1/20 0.33
▸ HTR3D Q70Z44 1/20 0.33
▸ HTR3C Q8WXA8 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23953236 0.83 HSD17B2 (0.46) HSD17B1HSD17B2IKBKBKDM4EMAPT
SCHEMBL23953229 0.82 MAPT (0.35) HSD17B1HSD17B2LMNAMAPTPKM
SCHEMBL2157824 0.78 POLB (0.62) HSD17B1HSD17B2CNR1LMNA
SCHEMBL2158507 0.78 FASN (0.43) HSD17B1HSD17B2LMNAPKMHTR3E
SCHEMBL2158434 0.77 FASN (0.42) HSD17B1HSD17B2LMNAPKM
SCHEMBL2157858 0.76 TACR1 (0.40) HSD17B1HSD17B2CNR1KDM4EMAPT
SCHEMBL2157908 0.76 HSD17B1 (0.44) HSD17B1HSD17B2
SCHEMBL2158629 0.76 HSD17B1 (0.47) HSD17B1HSD17B2CNR1LMNAMAPT
SCHEMBL11340441 0.76 AR (0.40) HSD17B1HSD17B2CNR1KDM4ELMNA
SCHEMBL2158030 0.75 CNR1 (0.52) HSD17B1HSD17B2CNR1KDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12415813-B2 Method for synthesizing thieno[3,2-b]pyridine-5(4H)-one derivative compound, using gold catalyst, and use therefor KOREA INSTITUTE OF OCEAN SCIENCE & TECHNOLOGY (KR) 2025-09-16 — — US disclosed
US-20210332063-A1 METHOD FOR SYNTHESIZING THIENO[3,2-B]PYRIDINE-5(4H)-ONE DERIVATIVE COMPOUND, USING GOLD CATALYST, AND USE THEREFOR KOREA INSTITUTE OF OCEAN SCIENCE & TECHNOLOGY (KP) 2021-10-28 — — US disclosed
US-20210332063-A1 METHOD FOR SYNTHESIZING THIENO[3,2-B]PYRIDINE-5(4H)-ONE DERIVATIVE COMPOUND, USING GOLD CATALYST, AND USE THEREFOR KOREA INSTITUTE OF OCEAN SCIENCE & TECHNOLOGY (KP) 2021-10-28 — — US disclosed
WO-2020036243-A1 METHOD FOR SYNTHESIZING THIENO[3,2-B]PYRIDINE-5(4H)-ONE DERIVATIVE COMPOUND, USING GOLD CATALYST, AND USE THEREFOR 한국해양과학기술원 2020-02-20 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210332063-A1 METHOD FOR SYNTHESIZING THIENO[3,2-B]PYRIDINE-5(4H)-ONE DERIVATIVE COMPOUND, USING GOLD CATALYST, AND USE THEREFOR FARS2, CYP4F11, CYP4B1 HSD17B1 2479/4885HSD17B2 2218/4885CNR1 3061/4885
US-12415813-B2 Method for synthesizing thieno[3,2-b]pyridine-5(4H)-one derivative compound, using gold catalyst, and use therefor FARS2, CYP4F11, CYP4B1 HSD17B1 2479/4885HSD17B2 2218/4885CNR1 3061/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.