Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 4/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.30 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
| ▸ | THPO | P40225 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alcohol SCHEMBL7320295 | 0.86 | — | — | |
| Alcohol SCHEMBL10569458 | 0.83 | ALDH1A1 (0.40) | ALDH1A1TDP1TSHRCHRM1CHRM2 | |
| Dimethylformamide SCHEMBL28282130 | 0.79 | TSHR (0.47) | ALDH1A1TDP1TSHRCHRM1CHRM2 | |
| Propane SCHEMBL27404624 | 0.76 | — | — | |
| Ethylene Glycol SCHEMBL7033601 | 0.74 | ALDH1A1 (0.39) | ALDH1A1TDP1TSHRCHRM1CHRM2 | |
| SCHEMBL28333523 | 0.73 | — | — | |
| Ethylene SCHEMBL18836924 | 0.73 | — | — | |
| SCHEMBL1332099 | 0.72 | — | — | |
| SCHEMBL1925147 | 0.72 | ALDH1A1 (0.50) | ALDH1A1TDP1TSHRCHRM1CHRM2 | |
| SCHEMBL30581185 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11999715-B2 | ASK1 inhibiting agents | BIOGEN MA INC. (US) | 2024-06-04 | — | — | US | disclosed |
| US-20240109867-A1 | ASK1 INHIBITING AGENTS | BIOGEN MA INC. | 2024-04-04 | — | — | US | disclosed |
| US-11897898-B2 | Pyridine macrocycle compounds as ASK1 inhibiting agents | BIOGEN MA INC. (US) | 2024-02-13 | — | — | US | disclosed |
| US-11814362-B2 | ASK1 inhibiting agents | BIOGEN MA INC. (US) | 2023-11-14 | — | — | US | disclosed |
| EP-3837251-B1 | ASK1 INHIBITING AGENTS | BIOGEN MA INC (US) | 2023-06-21 | — | — | EP | disclosed |
| EP-3837265-B1 | PYRIDINE MACROCYCLE COMPOUNDS AS ASK1 INHIBITING AGENTS | BIOGEN MA INC (US) | 2023-02-22 | — | — | EP | disclosed |
| US-20210317103-A1 | ASK1 INHIBITING AGENTS | BIOGEN MA INC. | 2021-10-14 | — | — | US | disclosed |
| US-20210300946-A1 | PYRIDINE MACROCYCLE COMPOUNDS AS ASK1 INHIBITING AGENTS | BIOGEN MA INC. | 2021-09-30 | — | — | US | disclosed |
| EP-3837251-A1 | ASK1 INHIBITING AGENTS | Biogen MA Inc. (US) | 2021-06-23 | — | — | EP | disclosed |
| EP-3837265-A1 | PYRIDINE MACROCYCLE COMPOUNDS AS ASK1 INHIBITING AGENTS | Biogen MA Inc. (US) | 2021-06-23 | — | — | EP | disclosed |
| US-20210115020-A1 | ASK1 INHIBITING AGENTS | BIOGEN MA INC. | 2021-04-22 | — | — | US | disclosed |
| WO-2020036946-A1 | PYRIDINE MACROCYCLE COMPOUNDS AS ASK1 INHIBITING AGENTS | BIOGEN MA INC. (US) | 2020-02-20 | — | — | WO | disclosed |
| WO-2020036949-A1 | ASK1 INHIBITING AGENTS | BIOGEN MA INC. (US) | 2020-02-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210317103-A1 | ASK1 INHIBITING AGENTS | MAP3K1, MAP3K6, MAP3K10 | ALDH1A1 2482/4885TDP1 148/4885TSHR 2691/4885 |
| US-11897898-B2 | Pyridine macrocycle compounds as ASK1 inhibiting agents | MAP3K1, MAP3K19, MAP3K20 | ALDH1A1 2878/4885TDP1 291/4885TSHR 2621/4885 |
| US-20210115020-A1 | ASK1 INHIBITING AGENTS | MAP3K1, MAP3K10, MAP3K20 | ALDH1A1 2661/4885TDP1 189/4885TSHR 2807/4885 |
| US-20210300946-A1 | PYRIDINE MACROCYCLE COMPOUNDS AS ASK1 INHIBITING AGENTS | MAP3K1, MAP3K19, MAP3K20 | ALDH1A1 2878/4885TDP1 291/4885TSHR 2621/4885 |
| US-11999715-B2 | ASK1 inhibiting agents | MAP3K1, MAP3K6, MAP3K10 | ALDH1A1 2482/4885TDP1 148/4885TSHR 2691/4885 |
| US-11814362-B2 | ASK1 inhibiting agents | MAP3K1, MAP3K10, MAP3K20 | ALDH1A1 2661/4885TDP1 189/4885TSHR 2807/4885 |
| US-20240109867-A1 | ASK1 INHIBITING AGENTS | MAP3K1, MAP3K10, MAP3K20 | ALDH1A1 2661/4885TDP1 189/4885TSHR 2807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.