Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.48 |
| ▸ | DRD3 | P35462 | 9/20 | 0.47 |
| ▸ | DRD2 | P14416 | 4/20 | 0.47 |
| ▸ | GPR4 | P46093 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21712258 | 0.90 | RXFP1 (0.51) | RXFP1ACKR3EPHX2DRD3DRD2 | |
| SCHEMBL3195004 | 0.87 | ALDH1A1 (0.50) | RXFP1MEN1GAAKMT2AEPHX2 | |
| SCHEMBL21740370 | 0.80 | DRD3 (0.44) | DRD3DRD2ADRB1HTR1AADRA2C | |
| SCHEMBL3196231 | 0.79 | DRD3 (0.50) | RXFP1EPHX2DRD3DRD2GPR4 | |
| SCHEMBL31298905 | 0.79 | NAMPT (0.47) | DRD2 | |
| SCHEMBL18135536 | 0.79 | KCNA5 (0.64) | MEN1KMT2AEPHX2DRD3DRD2 | |
| SCHEMBL31298894 | 0.79 | SCN9A (0.49) | DRD2ALDH1A1 | |
| SCHEMBL21712261 | 0.79 | MEN1 (0.43) | MEN1GAAKMT2ADRD3DRD2 | |
| SCHEMBL16676642 | 0.78 | RXFP1 (0.61) | RXFP1ACKR3MEN1GAAKMT2A | |
| SCHEMBL1495991 | 0.78 | KDM4E (0.46) | RXFP1ACKR3MEN1KMT2AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020036812-A1 | ACTIVATORS OF THE RETINOIC ACID INDUCIBLE GENE \"RIG-I\" PATHWAY AND METHODS OF USE THEREOF | Kineta, Inc. (US) | 2020-02-20 | — | — | WO | disclosed |