SCHEMBL2172455

SCHEMBL2172455

NC(=O)C1CCCN1c1ccc(Oc2ccc(F)cc2)cc1

nearest known ligand 0.60

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 10/20 0.60
FPR2 P25090 6/20 0.60
FFAR1 O14842 5/20 0.48
HTR1A P08908 1/20 0.47
HTR7 P34969 1/20 0.47
KCNH2 Q12809 1/20 0.46
F10 P00742 1/20 0.46
PARP10 Q53GL7 1/20 0.44
DPP4 P27487 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL2169819 0.99 SCN9A (0.59) SCN9AFPR2FFAR1HTR1AHTR7
SCHEMBL3047808 0.92 SCN9A (0.49) SCN9AFPR2HTR1AHTR7F10
SCHEMBL2170905 0.86 FFAR1 (0.62) SCN9AFPR2FFAR1F10
SCHEMBL15665295 0.82 F10 (0.58) FFAR1F10DPP4
SCHEMBL3061734 0.82 F10 (0.58) FFAR1F10DPP4
Trifluoroacetic Acid SCHEMBL30850139 0.80 SCN9A (0.43) SCN9AFPR2HTR1AHTR7F10
SCHEMBL17294200 0.78 SYK (0.46) F10DPP4
SCHEMBL77156 0.78 SYK (0.46) F10
SCHEMBL13723813 0.78 SYK (0.46) F10
SCHEMBL2169865 0.77 SCN9A (0.48) SCN9AFPR2KCNH2PARP10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2346821-A1 SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS Exelixis, Inc. (US) 2011-07-27 EP claimed
WO-2010045580-A1 SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS EXELIXIS, INC. (US) 2010-04-22 WO claimed
EP-2349252-A2 SYNERGISTIC COMBINATION OF SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS AND ANTIMICROTUBULE AGENTS Exelixis, Inc. (US) 2011-08-03 EP disclosed
EP-2346821-A1 SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS Exelixis, Inc. (US) 2011-07-27 EP disclosed
WO-2010045580-A1 SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS EXELIXIS, INC. (US) 2010-04-22 WO disclosed
WO-2010045601-A2 SYNERGISTIC EFFECTS BETWEEN SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS AND ANTIMICROTUBULE AGENTS EXELIXIS, INC. (US) 2010-04-22 WO disclosed