SCHEMBL2172637

SCHEMBL2172637

O=C1CSC(=S)N1CC(=O)N(C(=O)[C@@H]1C[C@@H](Cc2ccccc2)CN1)c1ccc(Oc2ccc(F)cc2)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSK3A P49840 6/20 0.38
GSK3B P49841 6/20 0.38
MEN1 O00255 5/20 0.34
KMT2A Q03164 5/20 0.34
GAA P10253 3/20 0.34
MAPT P10636 3/20 0.34
POLB P06746 2/20 0.34
HRH3 Q9Y5N1 3/20 0.34
CYP2D6 P10635 2/20 0.33
S1PR1 P21453 2/20 0.33
CYP2C9 P11712 1/20 0.33
CYP3A4 P08684 1/20 0.33
OPRM1 P35372 3/20 0.33
ALDH1A1 P00352 2/20 0.32
THRB P10828 2/20 0.32
HTT P42858 2/20 0.32
RECQL P46063 2/20 0.32
TDP1 Q9NUW8 2/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
LMNA P02545 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2350633 0.82 OPRM1 (0.39) MEN1KMT2AMAPTPOLBHRH3
SCHEMBL2353030 0.81 OPRM1 (0.37) MEN1KMT2APOLBHRH3CYP2D6
SCHEMBL2352992 0.80 MEN1 (0.37) MEN1KMT2APOLBHRH3CYP2D6
SCHEMBL2354130 0.79 OPRM1 (0.38) MEN1KMT2APOLBHRH3CYP2D6
SCHEMBL2352603 0.78 POLB (0.38) MEN1KMT2APOLBHRH3CYP2D6
SCHEMBL2357176 0.77 HRH3 (0.37) MEN1KMT2AMAPTPOLBHRH3
SCHEMBL2352589 0.75 POLB (0.37) MEN1KMT2APOLBHRH3CYP2D6
SCHEMBL2205673 0.75 S1PR1 (0.51) HRH3CYP2D6S1PR1CYP2C9CYP3A4
SCHEMBL2169856 0.74 CYP2C9 (0.45) HRH3CYP2D6S1PR1CYP2C9CYP3A4
SCHEMBL2172643 0.74 F2 (0.36) MEN1KMT2AGAAMAPTPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2349252-A2 SYNERGISTIC COMBINATION OF SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS AND ANTIMICROTUBULE AGENTS Exelixis, Inc. (US) 2011-08-03 EP disclosed
EP-2346821-A1 SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS Exelixis, Inc. (US) 2011-07-27 EP disclosed
WO-2010045580-A1 SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS EXELIXIS, INC. (US) 2010-04-22 WO disclosed
WO-2010045601-A2 SYNERGISTIC EFFECTS BETWEEN SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS AND ANTIMICROTUBULE AGENTS EXELIXIS, INC. (US) 2010-04-22 WO disclosed