Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | PARP1 | P09874 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 4/20 | 0.41 |
| ▸ | CASP7 | P55210 | 2/20 | 0.41 |
| ▸ | CASP2 | P42575 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | RGS12 | O14924 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5074783 | 0.84 | GSK3B (0.50) | GSK3BPARP1KDM4EALDH1A1HPGD | |
| SCHEMBL7078965 | 0.84 | GSK3B (0.50) | GSK3BPARP1KDM4EALDH1A1HPGD | |
| SCHEMBL30091416 | 0.84 | GSK3B (0.50) | GSK3BPARP1KDM4EALDH1A1HPGD | |
| SCHEMBL1024613 | 0.81 | GSK3B (0.46) | GSK3BPARP1KDM4EALDH1A1HPGD | |
| SCHEMBL17474487 | 0.81 | GSK3B (0.46) | GSK3BPARP1KDM4EALDH1A1HPGD | |
| SCHEMBL4421846 | 0.81 | KDM4E (0.47) | GSK3BPARP1KDM4EALDH1A1HPGD | |
| SCHEMBL4590268 | 0.78 | KDM4E (0.45) | GSK3BPARP1KDM4EALDH1A1HPGD | |
| SCHEMBL29016392 | 0.78 | GSK3B (0.43) | GSK3BPARP1KDM4EALDH1A1HPGD | |
| SCHEMBL16754925 | 0.77 | GSK3B (0.62) | GSK3BPARP1KDM4EALDH1A1HPGD | |
| SCHEMBL52296 | 0.77 | KDM4E (0.62) | GSK3BPARP1KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114315689-B | Disulfanylphthalimide compound, preparation method and application thereof | 四川大学 | 2023-04-07 | — | — | CN | claimed |
| CN-115724786-A | Amide alkane dithiophthalimide compound, preparation method and application thereof | 四川大学 | 2023-03-03 | — | — | CN | claimed |
| CN-114315689-A | Disulfanylphthalimide compound, preparation method and application thereof | 四川大学 | 2022-04-12 | — | — | CN | claimed |
| JP-2007505922-A | — | — | 2007-03-15 | — | — | JP | claimed |
| US-20060211728-A1 | Thalidomide analogs | P2D INC. | 2006-09-21 | — | — | US | claimed |
| EP-1663223-A2 | THALIDOMIDE ANALOGS AS TNF-ALPHA MODULATORS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE DEPARTMENT OF HEALTH & HUMAN SERVICES (US) | 2006-06-07 | — | — | EP | claimed |
| WO-2005028436-A2 | THALIDOMIDE ANALOGS AS TNF-ALPHA MODULATORS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2005-03-31 | — | — | WO | claimed |
| CN-115724786-B | Amidedithiophthalimide compound, preparation method and application thereof | 四川大学 | 2024-01-30 | — | — | CN | disclosed |
| CN-114315689-B | Disulfanylphthalimide compound, preparation method and application thereof | 四川大学 | 2023-04-07 | — | — | CN | disclosed |
| CN-114315689-B | Disulfanylphthalimide compound, preparation method and application thereof | 四川大学 | 2023-04-07 | — | — | CN | disclosed |
| CN-114315689-B | Disulfanylphthalimide compound, preparation method and application thereof | 四川大学 | 2023-04-07 | — | — | CN | disclosed |
| CN-115724786-A | Amide alkane dithiophthalimide compound, preparation method and application thereof | 四川大学 | 2023-03-03 | — | — | CN | disclosed |
| CN-115724786-A | Amide alkane dithiophthalimide compound, preparation method and application thereof | 四川大学 | 2023-03-03 | — | — | CN | disclosed |
| US-8546430-B2 | Thalidomide analogs | P2D, INC. (US) | 2013-10-01 | — | — | US | disclosed |
| US-20130035363-A1 | Thalidomide Analogs | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH & HUMAN SERVICES (US) | 2013-02-07 | — | — | US | disclosed |
| US-20110245210-A1 | THALIDOMIDE ANALOGS | The Government of the United States of America, as represented by the Secretary of | 2011-10-06 | — | — | US | disclosed |
| US-7973057-B2 | Thalidomide analogs | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-07-05 | — | — | US | disclosed |
| US-20060211728-A1 | Thalidomide analogs | P2D INC. | 2006-09-21 | — | — | US | disclosed |
| EP-1663223-A2 | THALIDOMIDE ANALOGS AS TNF-ALPHA MODULATORS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE DEPARTMENT OF HEALTH & HUMAN SERVICES (US) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005028436-A2 | THALIDOMIDE ANALOGS AS TNF-ALPHA MODULATORS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2005-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130035363-A1 | Thalidomide Analogs | TNF, TNFRSF1A, TNFRSF9 | GSK3B 2350/4885PARP1 1881/4885KDM4E 2768/4885 |
| US-20060211728-A1 | Thalidomide analogs | TNF, TNFRSF1A, PGF | GSK3B 3325/4885PARP1 2561/4885KDM4E 3440/4885 |
| US-20110245210-A1 | THALIDOMIDE ANALOGS | TNF, TNFRSF1A, PGF | GSK3B 3325/4885PARP1 2561/4885KDM4E 3440/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.