Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4A | O75164 | 1/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 6/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22551972 | 0.86 | KDM4A (0.41) | KDM4AMAPKAPK2L3MBTL1PRMT5WDR77 | |
| SCHEMBL29907501 | 0.86 | KDM4A (0.41) | KDM4AMAPKAPK2L3MBTL1PRMT5WDR77 | |
| SCHEMBL29112758 | 0.76 | CNR2 (0.41) | MAPKAPK2CA12CA1CA9 | |
| SCHEMBL1631864 | 0.76 | ADORA2A (0.48) | KDM4AL3MBTL1NAMPT | |
| SCHEMBL29112878 | 0.75 | GSK3B (0.41) | MAPKAPK2CA12CA1CA9 | |
| SCHEMBL29664294 | 0.73 | KDM4A (0.44) | KDM4AMAPKAPK2L3MBTL1KDM4ELMNA | |
| SCHEMBL31437524 | 0.72 | MAPKAPK2 (0.43) | KDM4AMAPKAPK2L3MBTL1PRMT5WDR77 | |
| SCHEMBL3124959 | 0.72 | ALDH1A1 (0.55) | KDM4AL3MBTL1KDM4ELMNAPOLB | |
| SCHEMBL2083332 | 0.70 | ADORA2A (0.43) | KDM4AMAPKAPK2L3MBTL1PRMT5WDR77 | |
| SCHEMBL16020337 | 0.70 | NAMPT (0.49) | KDM4AL3MBTL1KDM4ELMNANAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020035052-A1 | PYRAZINE COMPOUNDS AND USES THEREOF | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) | 2020-02-20 | — | — | WO | disclosed |