Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.55 |
| ▸ | MET | P08581 | 5/20 | 0.55 |
| ▸ | CSF1R | P07333 | 4/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.55 |
| ▸ | KDR | P35968 | 4/20 | 0.55 |
| ▸ | FLT3 | P36888 | 2/20 | 0.55 |
| ▸ | AXL | P30530 | 3/20 | 0.53 |
| ▸ | FLT4 | P35916 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | WNT3A | P56704 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.49 |
| ▸ | KIT | P10721 | 2/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2175586 | 0.93 | MET (0.57) | SMN1; SMN2KDM4ELMNATSHRMAPK1 | |
| SCHEMBL2176128 | 0.92 | MET (0.64) | SMN1; SMN2KDM4ELMNATSHRMAPK1 | |
| SCHEMBL5610715 | 0.85 | SMN1; SMN2 (0.55) | SMN1; SMN2KDM4ELMNATSHRMAPK1 | |
| SCHEMBL2176424 | 0.81 | AXL (0.62) | METCSF1RPDGFRBKDRFLT3 | |
| SCHEMBL1097598 | 0.79 | PDGFRB (0.65) | SMN1; SMN2KDM4ELMNATSHRMAPK1 | |
| SCHEMBL2172313 | 0.79 | PDGFRB (0.57) | METCSF1RPDGFRBKDRFLT3 | |
| SCHEMBL2175384 | 0.78 | FLT3 (0.64) | METCSF1RPDGFRBKDRFLT3 | |
| SCHEMBL2176657 | 0.78 | PDGFRB (0.66) | METCSF1RPDGFRBKDRFLT3 | |
| SCHEMBL2173476 | 0.78 | PDGFRB (0.67) | METCSF1RPDGFRBKDRFLT3 | |
| SCHEMBL2173233 | 0.77 | PDGFRB (0.86) | METCSF1RPDGFRBKDRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7973164-B2 | Quinoline derivatives | ASTRAZENECA AB (SE) | 2011-07-05 | — | — | US | disclosed |
| US-20090076074-A1 | QUINOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2009-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090076074-A1 | QUINOLINE DERIVATIVES | RECQL, NQO2, CCNA1 | SMN1; SMN2 2298/4885KDM4E 2492/4885LMNA 1122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.