Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 6/20 | 0.53 |
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 3/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.43 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1120636 | 0.82 | KIF11 (0.60) | KIF11SIRT1MEN1MAPTKMT2A | |
| SCHEMBL21732153 | 0.81 | KIF11 (0.56) | KIF11SIRT1MEN1MAPTKMT2A | |
| SCHEMBL21731958 | 0.80 | MAPT (0.51) | KIF11SIRT1MAPTSMN1; SMN2TP53 | |
| SCHEMBL21731609 | 0.77 | KIF11 (0.55) | KIF11SIRT1MEN1MAPTKMT2A | |
| SCHEMBL1120637 | 0.75 | KIF11 (0.61) | KIF11SIRT1HTR2AHTR2CSIRT2 | |
| SCHEMBL21731777 | 0.74 | KIF11 (0.66) | KIF11SIRT1MEN1MAPTKMT2A | |
| SCHEMBL21731769 | 0.74 | HTR2A (0.57) | KIF11SIRT1MEN1MAPTKMT2A | |
| SCHEMBL21731513 | 0.73 | KIF11 (0.50) | KIF11SIRT1HTR2AHTR2CESR1 | |
| SCHEMBL12456417 | 0.73 | KIF11 (0.51) | KIF11SIRT1HTR2AHTR2C | |
| SCHEMBL12456418 | 0.73 | KIF11 (0.51) | KIF11SIRT1HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020037155-A1 | 1,3,4,9-TETRAHYDRO-2H-PYRIDO[3,4-B]INDOLE DERIVATIVE COMPOUNDS AND USES THEREOF | RECREO PHARMACEUTICALS LLC (US) | 2020-02-20 | — | — | WO | disclosed |