Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 19/20 | 0.55 |
| ▸ | JAK2 | O60674 | 5/20 | 0.54 |
| ▸ | NTRK3 | Q16288 | 4/20 | 0.50 |
| ▸ | NTRK2 | Q16620 | 4/20 | 0.50 |
| ▸ | INSR | P06213 | 1/20 | 0.50 |
| ▸ | LYN | P07948 | 1/20 | 0.50 |
| ▸ | RET | P07949 | 1/20 | 0.50 |
| ▸ | MET | P08581 | 1/20 | 0.50 |
| ▸ | ROS1 | P08922 | 1/20 | 0.50 |
| ▸ | FGR | P09769 | 1/20 | 0.50 |
| ▸ | KIT | P10721 | 1/20 | 0.50 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.50 |
| ▸ | TIE1 | P35590 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.50 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21723127 | 1.00 | NTRK1 (0.55) | NTRK1JAK2NTRK3NTRK2INSR | |
| SCHEMBL21732087 | 0.87 | NTRK1 (0.54) | NTRK1JAK2NTRK3NTRK2INSR | |
| SCHEMBL21723201 | 0.87 | NTRK1 (0.54) | NTRK1JAK2NTRK3NTRK2INSR | |
| SCHEMBL21732262 | 0.81 | NTRK1 (0.54) | NTRK1JAK2NTRK3NTRK2INSR | |
| SCHEMBL433407 | 0.81 | NTRK1 (0.64) | NTRK1JAK2NTRK3NTRK2INSR | |
| SCHEMBL21732090 | 0.80 | NTRK1 (0.51) | NTRK1JAK2NTRK3NTRK2INSR | |
| SCHEMBL21732089 | 0.78 | NTRK1 (0.52) | NTRK1JAK2NTRK3NTRK2INSR | |
| SCHEMBL21723125 | 0.78 | NTRK1 (0.52) | NTRK1JAK2NTRK3NTRK2INSR | |
| SCHEMBL23632314 | 0.77 | SCN9A (0.51) | NTRK1JAK2NTRK3NTRK2RIPK1 | |
| SCHEMBL31444355 | 0.77 | SMO (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020035557-A1 | NOVEL HETEROAROMATIC MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA | LEO PHARMA A/S (DK) | 2020-02-20 | — | — | WO | disclosed |