Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | PLAT | P00750 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19002873 | 0.95 | OPRM1 (0.39) | OPRM1OPRD1OPRK1OPRL1AOC3 | |
| SCHEMBL18647927 | 0.93 | OPRM1 (0.38) | OPRM1OPRD1OPRK1OPRL1AOC3 | |
| SCHEMBL17320101 | 0.93 | AOC3 (0.42) | AOC3HDAC4HDAC7HDAC5IDO1 | |
| SCHEMBL21555772 | 0.92 | OPRM1 (0.41) | OPRM1OPRD1OPRK1OPRL1AOC3 | |
| SCHEMBL19101512 | 0.90 | OPRM1 (0.39) | OPRM1OPRD1OPRK1OPRL1AOC3 | |
| SCHEMBL21555784 | 0.90 | OPRM1 (0.39) | OPRM1OPRD1OPRK1OPRL1AOC3 | |
| SCHEMBL19003606 | 0.86 | AOC3 (0.41) | AOC3HDAC4HDAC7HDAC5IDO1 | |
| SCHEMBL7538162 | 0.83 | SLC6A2 (0.43) | OPRM1OPRD1OPRK1OPRL1AOC3 | |
| SCHEMBL7538156 | 0.83 | AOC3 (0.39) | OPRM1OPRD1OPRK1OPRL1AOC3 | |
| SCHEMBL11994155 | 0.82 | CYP19A1 (0.48) | OPRM1OPRD1OPRK1OPRL1AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020035557-A1 | NOVEL HETEROAROMATIC MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA | LEO PHARMA A/S (DK) | 2020-02-20 | — | — | WO | disclosed |