Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 3/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.36 |
| ▸ | KDM1A | O60341 | 3/20 | 0.35 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21723496 | 0.86 | NTRK1 (0.44) | NTRK1JAK2NOS3SLC6A9MAOB | |
| SCHEMBL30898796 | 0.84 | NTRK1 (0.47) | NTRK1JAK2SLC6A9MAOBMAOA | |
| SCHEMBL23632045 | 0.84 | NTRK1 (0.47) | NTRK1JAK2SLC6A9MAOBMAOA | |
| SCHEMBL21732293 | 0.82 | NTRK1 (0.46) | NTRK1JAK2SLC6A9MAOBMAOA | |
| SCHEMBL21723165 | 0.81 | NTRK1 (0.47) | NTRK1JAK2TAAR1NOS3SLC6A9 | |
| SCHEMBL23632049 | 0.78 | NTRK1 (0.45) | NTRK1JAK2SLC6A9ALDH1A1MAPT | |
| SCHEMBL21732252 | 0.78 | NTRK1 (0.48) | NTRK1JAK2NOS3SLC6A9RIPK1 | |
| SCHEMBL21723222 | 0.78 | NTRK1 (0.48) | NTRK1JAK2NOS3SLC6A9RIPK1 | |
| SCHEMBL21732255 | 0.78 | NTRK1 (0.48) | NTRK1JAK2NOS3SLC6A9RIPK1 | |
| SCHEMBL448839 | 0.77 | NTRK1 (0.48) | NTRK1JAK2NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020035557-A1 | NOVEL HETEROAROMATIC MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA | LEO PHARMA A/S (DK) | 2020-02-20 | — | — | WO | disclosed |