SCHEMBL21732293

SCHEMBL21732293

CONc1cnc(N2CC(F)(F)CC2c2cccc(F)c2)nc1

nearest known ligand 0.46

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
NTRK1 P04629 4/20 0.46
JAK2 O60674 3/20 0.46
MAOB P27338 2/20 0.36
OPRK1 P41145 1/20 0.36
MAOA P21397 1/20 0.36
SLC6A9 P48067 3/20 0.35
BCHE P06276 1/20 0.35
ACHE P22303 1/20 0.35
ROCK2 O75116 2/20 0.34
RIPK1 Q13546 1/20 0.34
HTR7 P34969 1/20 0.34
GRM5 P41594 2/20 0.34
POLB P06746 2/20 0.34
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21723496 0.82 NTRK1 (0.44) NTRK1JAK2MAOBMAOASLC6A9
SCHEMBL21732102 0.82 NTRK1 (0.44) NTRK1JAK2MAOBMAOASLC6A9
SCHEMBL21732202 0.82 NTRK1 (0.44) NTRK1JAK2MAOBMAOASLC6A9
SCHEMBL21732277 0.81 NTRK1 (0.51) NTRK1JAK2RIPK1
SCHEMBL23632045 0.81 NTRK1 (0.47) NTRK1JAK2MAOBMAOASLC6A9
SCHEMBL30898796 0.81 NTRK1 (0.47) NTRK1JAK2MAOBMAOASLC6A9
SCHEMBL21732101 0.80 JAK2 (0.38) NTRK1JAK2MAOBMAOASLC6A9
SCHEMBL23632049 0.79 NTRK1 (0.45) NTRK1JAK2SLC6A9BCHEACHE
SCHEMBL23642468 0.72 RORC (0.48) NTRK1JAK2
SCHEMBL21723165 0.71 NTRK1 (0.47) NTRK1JAK2MAOBMAOASLC6A9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020035557-A1 NOVEL HETEROAROMATIC MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA LEO PHARMA A/S (DK) 2020-02-20 WO disclosed