Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 18/20 | 0.62 |
| ▸ | PNMT | P11086 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.39 |
| ▸ | IL17A | Q16552 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21732180 | 0.79 | RORC (0.47) | RORC | |
| SCHEMBL21732083 | 0.78 | RORC (0.64) | RORCCYP2D6IL17AKCNH2 | |
| SCHEMBL21729689 | 0.77 | RORC (0.58) | RORCCYP2D6IL17A | |
| SCHEMBL21729690 | 0.77 | RORC (0.58) | RORCCYP2D6IL17A | |
| SCHEMBL29758649 | 0.76 | RORC (1.00) | RORCCYP2D6IL17AKCNH2 | |
| SCHEMBL18939880 | 0.76 | RORC (1.00) | RORCCYP2D6IL17AKCNH2 | |
| Hydrochloric Acid SCHEMBL18940116 | 0.76 | RORC (0.98) | RORCCYP2D6IL17AKCNH2 | |
| SCHEMBL18961547 | 0.76 | RORC (0.84) | RORCCYP2D6IL17AKCNH2 | |
| SCHEMBL18961493 | 0.76 | RORC (0.84) | RORCCYP2D6IL17AKCNH2 | |
| SCHEMBL21732071 | 0.75 | RORC (0.49) | RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020035557-A1 | NOVEL HETEROAROMATIC MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA | LEO PHARMA A/S (DK) | 2020-02-20 | — | — | WO | disclosed |